Can you use water instead of milk in biscuit mix?

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Substitute an equal amount of water for the milk in Bisquick. Imagine you're ready to whip up a batch of biscuits or pancakes using Bisquick baking mix only to find you're out of milk! Not to worry, you can still make Bisquick pancakes without milk, as well as other baked goods.
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To prepare, add 1 cup of water and stir until it comes together. Give the mixture a few quick kneads just to smooth it out, and then roll the biscuits out on a floured surface. Cut and bake for 12-14 minutes at 400 degrees F.
If you are going to substitute a non-cultured liquid into your biscuits, I’d strongly recommend using low-fat milk, or even whole milk, instead of cream. Both will give you a more pleasant biscuit, with just the right amount of fat that you’ll still want to slather the inside with butter.